Computational and Mathematical Methods in Medicine
Volume 2012 (2012), Article ID 859398, 8 pages
Review Article

Motion Analysis of Live Objects by Super-Resolution Fluorescence Microscopy

1Key Laboratory of E&M, Zhejiang University of Technology, Ministry of Education and Zhejiang Province, Hangzhou 310014, China
2Department of Informatics, University of Hamburg, 22527 Hamburg, Germany
3Guangxi Academy of Sciences, 98 Daling Road, Nanning 530007, China
4DreamSciTech Consulting, Shenzhen 518054, China
5Department of Technology and Nautical Sciences, Aalesund University College, 26025 Aalesund, Norway

Received 1 September 2011; Accepted 26 September 2011

Academic Editor: Carlo Cattani

Copyright © 2012 Chunyan Yao et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Motion analysis plays an important role in studing activities or behaviors of live objects in medicine, biotechnology, chemistry, physics, spectroscopy, nanotechnology, enzymology, and biological engineering. This paper briefly reviews the developments in this area mostly in the recent three years, especially for cellular analysis in fluorescence microscopy. The topic has received much attention with the increasing demands in biomedical applications. The tasks of motion analysis include detection and tracking of objects, as well as analysis of motion behavior, living activity, events, motion statistics, and so forth. In the last decades, hundreds of papers have been published in this research topic. They cover a wide area, such as investigation of cell, cancer, virus, sperm, microbe, karyogram, and so forth. These contributions are summarized in this review. Developed methods and practical examples are also introduced. The review is useful to people in the related field for easy referral of the state of the art.